Intrathecal delivery of nusinersen using the Ommaya reservoir in a spinal muscular atrophy type 2 patient: a case report
10.3760/cma.j.cn113694-20220926-00724
- VernacularTitle:脊髓蛛网膜下腔植入Ommaya囊注射诺西那生治疗脊髓性肌萎缩2型患者1例
- Author:
Ning YANG
1
;
Haoyong JIN
;
Chao ZHANG
;
Yuying ZHAO
;
Ying HOU
;
Yaning ZHANG
;
Hui WANG
;
Dongliang LI
;
Shujun XU
;
Xingang LI
;
Chao LI
Author Information
1. 山东大学齐鲁医院神经外科，济南 250012
- Keywords:
Spinal muscular atrophies;
Ommaya reservoir;
Scoliosis deformity;
Nusinersen;
Intrathecal injection
- From:
Chinese Journal of Neurology
2023;56(6):695-698
- CountryChina
- Language:Chinese
-
Abstract:
Ommaya reservoir implantation is generally used in the treatment of hydrocephalus and intraventricular drug administration. Ommaya reservoir implantation in the subarachnoid space of the spinal cord for the intrathecal drug administration has not been carried out in China, and only several reports can be retrieved from PubMed. About 60%-90% of untreated patients with spinal muscular atrophy type 2 (SMA2) who survive to adulthood often have complex scoliosis and joint deformities. Nusinersen is an effective drug for the treatment of SMA2. And the route of administration is intrathecal injection, which is difficult for patients with severe scoliosis. This article summarizes the process of Ommaya reservoir implantation and postoperative drug administration in a patient with complex scoliosis type SMA2, which provides a new method for clinical treatment of this disease.
