Current researches of the role of dural immunity in neuroinfectious and neuroimmune diseases
10.3760/cma.j.cn113694-20230216-00103
- VernacularTitle:硬脑膜免疫在神经感染和免疫性疾病中的作用研究
- Author:
Hanxiao CAI
1
;
Wenmian HUANG
;
Tao LIU
;
Yutao DU
;
Guodong FENG
Author Information
1. 复旦大学附属中山医院神经内科，上海 200032
- Keywords:
Central nervous system diseases;
Central nervous system infections;
Meninges;
Immunity, cellular;
Lymphatic vessels
- From:
Chinese Journal of Neurology
2023;56(5):572-577
- CountryChina
- Language:Chinese
-
Abstract:
Dura mater, rich in vasculature and immune cells, is the outermost layer of the central nervous system, and thus acts as the first barrier to protect brain. Meningeal lymphatic vessels and immune cells are main components of dural immunity, which respond to a variety of central nervous system diseases. Meanwhile, compared with brain parenchyma, dura mater communicates more with peripheral tissues and is more susceptible to medical interventions. Therefore, dura mater is a promising target to prevent, diagnose and treat intracranial diseases. Here dural immunity is clarified based on meningeal lymphatic vessels and dural immune cells, and current researches inquiring the role of dural immunity in infectious and immune diseases of central nervous system are summarized.
