Drug-induced peripheral neuropathy
10.3760/cma.j.cn113694-20230221-00114
- VernacularTitle:药物相关性周围神经病
- Author:
Zuneng LU
1
Author Information
1. 武汉大学人民医院神经科，武汉 430060
- Keywords:
Peripheral neuropathy;
Drug;
Chemotherapy
- From:
Chinese Journal of Neurology
2023;56(5):557-561
- CountryChina
- Language:Chinese
-
Abstract:
There are many causes of peripheral neuropathy, one of which is that caused by various therapeutic drugs, namely drug-induced peripheral neuropathy (DIPN). With the increasing number of cancer patients, chemotherapy-induced peripheral neuropathy (CIPN) is prominent. Most of DIPN showed chronic, sensory and axonal polyneuropathy, and numbness and neuropathic pain were the main symptoms. The medical history of drug exposure and related risk factors are the key to clinical diagnosis. DIPN caused by non-chemotherapy drugs must be stopped in time to prevent further dysfunction. For CIPN, no agents are recommended for the prevention; the appropriateness of dose delaying and reduction, substitutions or stopping chemotherapy should be evaluated; duloxetine is the only agent that has appropriate evidence to support its use, whereas the amount of benefit is limited. It is urgent to perform the multidisciplinary randomized clinical trial for the treatment of CIPN.
