Vigabatrin-associated brain abnormalities on magnetic resonance imaging in the treatment of infantile spasms: a case report
10.3760/cma.j.cn113694-20220731-00585
- VernacularTitle:氨己烯酸治疗婴儿痉挛症致头颅磁共振成像异常1例
- Author:
Xiaoping YANG
1
;
Huifen WANG
;
Huifang WANG
;
Yating ZHANG
;
Qiong WANG
;
Meizhen SUN
;
Junhong GUO
;
Yi YAO
;
Xiaoping DU
Author Information
1. 山西医科大学第一医院神经内科，太原 030001
- Keywords:
Vigabatrin;
Spasms, infantile;
Magnetic resonance imaging;
Adverse events
- From:
Chinese Journal of Neurology
2023;56(4):438-441
- CountryChina
- Language:Chinese
-
Abstract:
Vigabatrin-associated brain abnormalities on magnetic resonance imaging (VABAM) is a relatively rare side effect of vigabatrin, most of which are asymptomatic. However, there will be extremely rare cases with hyperkinetic disorders, myoclonus, tremor, and acute encephalopathy under certain circumstances. VABAM is often underappreciated by physicians and its accurate incidence remains unclear. A female infant who was diagnosed with infantile spasms and required adrenocorticotropic hormone therapy accompanied by various antiseizure medicines was reported. Unfortunately, she became lethargic and her spasm deteriorated gradually after vigabatrin exposure. Her brain magnetic resonance imaging revealed abnormal signals bilaterally in the dorsal midbrain, thalamus, and rostral part of the pallidum. She had a seizure amelioration and became lively as a result of vigabatrin withdrawal. In the meanwhile, magnetic resonance imaging returned to normal. Attempts were made to discover the risk factors of VABAM and potential pathogenesis. Further understanding of the disease should contribute to decreasing misdiagnosis and making precise decisions.
