Research progress of microglia regulating phagocytosis of apoptotic neurons after intracerebral hemorrhage
10.3760/cma.j.cn113694-20220609-00467
- VernacularTitle:脑出血后小胶质细胞调控凋亡神经元吞噬作用的研究进展
- Author:
Jincheng MENG
1
;
Chong ZHANG
;
Sinan JIN
;
Wei HUA
;
He WU
Author Information
1. 哈尔滨医科大学附属第一医院病理科，哈尔滨 150007
- Keywords:
Cerebral hemorrhage;
Phagocytosis;
Apoptosis;
Phosphatidylserines;
Microglia
- From:
Chinese Journal of Neurology
2023;56(2):198-203
- CountryChina
- Language:Chinese
-
Abstract:
Intracerebral hemorrhage is the bleeding caused by spontaneous non-traumatic rupture of blood vessels in brain parenchyma. It has high disability rate and mortality. A series of injuries after intracerebral hemorrhage will lead to neuronal apoptosis. If apoptotic neurons are not cleared in time, intracellular toxic substances will be released, thereby further aggravating the inflammatory reaction. Therefore, the timely clearance of apoptotic cells is of great significance to the brain homeostasis after intracerebral hemorrhage. At the same time, a large number of phagocytic "eat me" signal phosphatidylserine (PS) will appear on the surface of apoptotic neurons. Microglia, as resident macrophages in the brain, have a variety of PS receptors on their surface, which promote the phagocytosis of apoptotic neurons by microglia and reduce the occurrence of local inflammatory responses.
