Progress of cyclic adenosine monophosphate responsive element binding protein in the pathogenesis of drug-resistant epilepsy
10.3760/cma.j.cn113694-20221020-00780
- VernacularTitle:环磷酸腺苷反应元件结合蛋白在耐药性癫痫发病机制中的作用研究进展
- Author:
Jingxuan LI
1
;
Dai SHI
;
Guofeng WU
Author Information
1. 贵州医科大学临床医学院，贵阳550001
- Keywords:
Epilepsy;
gamma-Aminobutyric acid;
Brain-derived neurotrophic factor;
Calmodulin-binding proteins;
Cyclic adenosine monophosphate responsive element bindi
- From:
Chinese Journal of Neurology
2023;56(1):111-117
- CountryChina
- Language:Chinese
-
Abstract:
Recent studies have found that in the development of epilepsy, cyclic adenosine monophosphate response element binding protein (CREB) may cause recurrent epilepsy by inhibiting the expression of γ-aminobutyric acid, resulting in neuron damage and weakened effect of antiepileptic drug targets. Antiepileptic drugs can not control the extent or frequency of seizures, and then the patients are in a persistent state, hence the development of drug-resistant epilepsy. Therefore, the mechanism of CREB leading to drug-resistant epilepsy was reviewed in this paper, hoping to provide ideas for the treatment of drug-resistant epilepsy patients.
