Research progress on involvement of pedunculopontine tegmental nucleus in dystonia
10.3760/cma.j.cn113694-20220517-00398
- VernacularTitle:脚桥核参与肌张力障碍发病的研究进展
- Author:
Junhui SU
1
;
Yaowen HU
;
Yi YANG
;
Fei TENG
;
Lingjing JIN
Author Information
1. 同济大学附属同济医院神经内科，上海 200065
- Keywords:
Pedunculopontine tegmental nucleus;
Muscle tone;
Dystonia;
Parkinson disease
- From:
Chinese Journal of Neurology
2023;56(1):88-93
- CountryChina
- Language:Chinese
-
Abstract:
As the major part of mesencephalic locomotion region, pedunculopontine tegmental nucleus (PPN) participates in motor initiation, rhythmic and speed regulation. In addition, PPN is regarded as a novel deep brain stimulation target for patients with Parkinson′s disease due to its dramatic effect on the gait disturbance and postural instability. However, PPN also has an important role in muscle tone control and dystonia. This review is aimed at summarizing the involvement of PPN in dystonia, providing fundamental for targeting PPN for treatment of dystonia in the future.
