Clinical analysis of 6 cases with factor Ⅴ deficiency
10.3760/cma.j.cn114798-20230313-00205
- VernacularTitle:凝血因子Ⅴ缺乏症6例临床特征分析
- Author:
Weiwei JIA
1
;
Qilong LI
;
Xiangxiang ZHOU
;
Xinguo CHEN
;
Bangzhen MA
Author Information
1. 山东第一医科大学附属省立医院医务部，济南 250021
- Keywords:
Factor Ⅴ deficiency;
Hemorrhage;
Clinical features
- From:
Chinese Journal of General Practitioners
2023;22(9):964-966
- CountryChina
- Language:Chinese
-
Abstract:
Six patients with factor Ⅴ deficiency were admitted in Shandong Provincial Hospital Affiliated to Shandong First Medical University from January 2006 to December 2022. All 6 patients presented with symptoms of coagulation dysfunction, 4 patients had recurrent nose bleeding, gingival bleeding, skin ecchymosis as the main manifestations, 1 patient had lower abdominal pain and ovarian active bleeding, and 1 patient had heavy menstruation. The prothrombin time and activated partial thromboplastin time were significantly prolonged, the factor Ⅴ level was significantly lower than normal, and the thrombin time was basically normal in all patients. Four patients received non-surgical treatment and transfusion of fresh frozen plasma; the bleeding symptoms were significantly relieved during hospitalization, and no aggravation of bleeding symptoms was found during follow-up. One patient with active ovarian hemorrhage underwent emergency surgical suture to stop bleeding, and fresh frozen plasma and prothrombin complex were given perioperatively; and no more bleeding occurred during follow-up. One patients with excessive menstruation underwent curettage plus hysteroscopic endometrial ablation, and the amount of menstruation was significantly reduced. It is suggested that the bleeding symptoms of coagulation factor Ⅴ deficiency vary in severity, which can be effectively alleviated by infusion of the fresh frozen plasma in most cases.
