Correlation between vaccination doses and duration of positive nucleic acid or antigen tests among COVID-19 patients
10.3760/cma.j.cn114798-20230111-00050
- VernacularTitle:新型冠状病毒感染者疫苗接种针次与核酸或抗原检测阳性持续时间的关联研究
- Author:
Min DU
1
;
Shugang LI
;
Wenwei ZHU
;
Fangjun WAN
;
Mingyue LI
;
Chen WANG
;
Hao WU
;
Jue LIU
;
Jianhui WANG
Author Information
1. 北京大学公共卫生学院，北京100191
- Keywords:
Vaccines;
Pathogenesis;
Corona Virus Disease 2019
- From:
Chinese Journal of General Practitioners
2023;22(5):467-473
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between vaccination doses and the duration of positive nucleic acid or antigen tests in Corona Virus Disease 2019 (COVID-19) patients during omicron epidemic.Methods:A cross-sectional study was conducted from December 26 to December 31, 2022 among COVID-19 patients from all community health service centers in 16 districts of Beijing municipality selected by multi-stage stratified cluster quota sampling method. A questionnaire was used to collect the basic information, vaccination doses, results of nucleic acid or antigen tests of all subjects. The subjects were divided into 5 groups according to the doses of COVID-19 vaccination: the non-vaccination group, the 1, 2, 3 and 4 doses vaccination group. The relationship between vaccination doses and the duration of positive nucleic acid or antigen tests was analyzed by univariate and multivariate logistic regression models.Results:A total of 10 506 COVID-19 cases were included in the study with the age of (43.3±13.7) years. The duration of positive nucleic acid or antigen tests was longer than 7 days in 59.4%(276/465), 51.5%(67/130), 50.6%(355/701), 46.1% (3 464/7 520) and 39.2%(662/1 690) of non-vaccination, and 1, 2, 3, 4 dose vaccination groups, respectively ( P<0.001). Multivariate logistic regression analysis showed that compared with non-vaccination patients, the vaccination dose was an independent protective factor for duration of positive nucleic acid or antigen tests>7 days, and the OR values were 0.7 (95% CI 0.5-0.9, P=0.015), 0.6 (95% CI 0.5-0.8, P<0.001) and 0.5 (95% CI 0.4-0.6, P<0.001) for 2, 3 and 4 doses of vaccination, respectively. Conclusion:The vaccination doses are independently related to the duration of positive nucleic acid or antigen tests in COVID-19 patients and the risk is gradually decreases with the increasing vaccination doses.
