Clinical characteristics of hospitalized premenopausal patients with hyperuricemia
10.3760/cma.j.cn114798-20220407-00274
- VernacularTitle:绝经前高尿酸血症住院患者的临床特点分析
- Author:
Yue YIN
1
;
Weixin LIU
;
Juan WU
;
Xinxin HAN
;
Yu CAO
;
Xiaotian CHU
;
Yun ZHANG
;
Xuejun ZENG
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院全科医学科（普通内科）疑难重症及罕见病国家重点实验室（北京协和医院），北京 100730
- Keywords:
Premenopausal, women;
Hyperuricemia;
Secondary factors
- From:
Chinese Journal of General Practitioners
2023;22(1):56-61
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the clinical characteristics of hospitalized premenopausal patients with hyperuricemia.Methods:The medical records of premenopausal women with hyperuricemia (serum uric acid ≥360 μmol/L during hospitalization) admitted in Peking Union Medical College Hospital from 2013 to 2018 were reviewed and the clinical data were analyzed.Results:A total of 2 099 patients were enrolled. Only 14.01% (294 cases) of the patients were concerned about hyperuricemia by physicians. Autoimmune diseases (32.11%, 674 cases), nephrotic disease (19.29%, 405 cases) and endocrine system diseases (9.72%, 204 cases) are the main reasons for hospitalization, while 6.34%(133 cases) of patients were in gestation. In terms of the etiology, renal diseases (49.35%, 1 035 cases), specific drug use (49.26%, 1 034 cases) were the main causes of secondary hyperuricemia in premenopausal women, followed by metabolic diseases (10.62%, 233 cases). There was no significant difference in serum uric acid level among premenopausal women of different ages ( H=4.47, P=0.107), but the etiology of hyperuricemia among patients of different ages had significant differences. The proportion of hyperuricemia in patients with cancer and metabolic syndrome,secondary to use of diuretics and anti-tuberculosis drugs had differences among different age groups ( χ2=90.96,52.89,19.26 and 6.41, P<0.05). Conclusion:Hyperuricemia is not uncommon in premenopausal women. There are many secondary factors leading to hyperuricemia in premenopausal women, among which drugs and renal lesions are the main causes. In addition, the secondary factors in women with hyperuricemia has differences among different age groups.
