Effect of acute kidney injury on near-term prognosis of the recipients with idiopathic pulmonary fibrosis after lung transplantation
10.3760/cma.j.cn421203-20221111-00294
- VernacularTitle:特发性肺纤维化肺移植受者术后急性肾损伤对早期预后的影响
- Author:
Chunlan HU
1
;
Jing WANG
;
Xiaoshan LI
;
Huizhi YU
;
Bo XU
;
Dongxiao HUANG
;
Feng LIU
;
Chunxiao HU
;
Jingyu CHEN
Author Information
1. 南京医科大学附属无锡人民医院麻醉科，无锡 214023
- Keywords:
Lung transplantation;
Acute kidney injury;
Idiopathic Pulmonary Fibrosis
- From:
Chinese Journal of Organ Transplantation
2023;44(5):283-290
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of acute kidney injury(AKI)on near-term survival after lung transplantation(LT)in patients with idiopathic pulmonary fibrosis(IPF).Methods:Through consulting electronic medical records, anesthetic modes and Chinese Lung Transplant Registration System, clinical data are retrospectively reviewed for 275 IPF patients undergoing LT at Affiliated Wuxi People's Hospital of Nanjing Medical University from January 2017 to April 2021.According to the diagnostic criteria of Kidney Disease: Improving Global Outcomes(KDIGO), they are divided into two groups of AKI(169 cases)and non-AKI(106 cases).Perioperative findings of two groups are recorded.Then univariate and multivariate Cox regression models are employed for determining whether or not inter-group differences existed in survival rates post-LT.Also AKI is staged according to the KDIGO.And the effect of stage 1/2/3 AKI on near-term postoperative prognosis is examined.Results:The differences are significantly different in recipient gender, creatinine, 6-minute walking test, forced vital capacity(FVC), lung allocation score, oxygenation index, N-terminal pro-brain natriuretic peptide(NT-Pro BNP), preoperative hormone use and volume of crystal infusion( P<0.05).After multivariate Cox regression correcting for covariates, no statistical significance exists in effect of AKI stage 1 on near-term postoperative survival rate( P<0.05).AKI stage 2/3 still has statistical significance in risk of mortality at Day 30/90/180/365 post-operation( P>0.05). Conclusions:As a common complication post-LT, AKI significantly affects near-term postoperative prognosis of transplant IPF patients.Stage 2/3 AKI impacts near-term postoperative survival while stage 1 AKI is not associated with higher mortality.
