Risk factors for early acute kidney injury after classic orthotopic liver transplantation
10.3760/cma.j.cn421203-20221230-00343
- VernacularTitle:肝移植术后早期急性肾损伤的危险因素分析
- Author:
Jiahong CHEN
1
;
Ying XU
;
Songzhe HE
;
Tao LI
;
Yunhao BAI
;
Xiangqin SONG
;
Tiantian ZHAO
;
Wei LI
;
Hongtao JIANG
;
Yi WANG
Author Information
1. 海南医学院第二附属医院肾移植科，海口 570311
- Keywords:
Liver transplantation;
Acute kidney injury;
Risk factor;
Anhepatic phase
- From:
Chinese Journal of Organ Transplantation
2023;44(5):269-274
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the risk factors affecting the incidence of acute kidney injury(AKI)after liver transplantation(LT).Methods:From November 2019 to November 2022, clinical data were retrospectively reviewed for 105 recipients of classic orthotopic LT.There are 89 males and 16 females with an age range of(50.52±10.35)years.They are assigned into two groups of AKI(66 cases)and non-AKI(39 cases)according to the AKI diagnostic and staging criteria of Global Kidney Disease Prognosis Organization in 2012.General profiles and clinical data(e.g.previous medical history, MELD score, total bilirubin, albumin, serum creatinine level, coagulation function, anhepatic phase and time to surgery)of two groups of recipients are compared.The factors with statistically significant differences are included into multivariate Logistic regression analysis for obtaining independent risk factors for early AKI post-LT.Results:Among them, 66 patients developed AKI within 7 days post-operation with an incidence rate of 62.86%(66/105).The clinical stages of AKI are Ⅰ(46 cases, 69.70%), Ⅱ(10 cases, 15.15%)and Ⅲ(10 cases, 15.15%).Statistically significant inter-group differences exists in age, abdominal surgery history, preoperative serum level of creatinine, operative duration, anhepatic phase and intraoperative plasma transfusion(all P<0.05).Multivariate Logistic regression analysis indicated that abdominal surgery history( OR=5.803, 95% CI: 1.008~33.401, P=0.049), anhepatic phase( OR=1.054, 95% CI: 1.008~1.101, P=0.020)and preoperative serum level of creatinine( OR=0.968, 95% CI: 0.943~0.994, P=0.016)are independent risk factors for early AKI after classical orthotopic LT recipients. Conclusions:Abdominal surgery history, anhepatic phase, and preoperative serum level of creatinine are independent risk factors for early AKI in classic orthotopic LT recipients.
