Effect of parental donor liver on early acute cellular rejection after live donor liver transplantation in infants
10.3760/cma.j.cn421203-20220923-00238
- VernacularTitle:父母供肝对1岁内儿童活体肝移植术后早期急性细胞排斥反应的影响
- Author:
Lijun JIAO
1
;
Chong DONG
;
Kai WANG
;
Chao SUN
;
Wei ZHANG
;
Weiping ZHENG
;
Zhen WANG
;
Enbo XIE
;
Min XU
;
Wei GAO
Author Information
1. 天津市第一中心医院儿童器官移植科，天津 300192
- Keywords:
Liver transplantation;
Child;
Living donated liver;
Acute cellular rejection
- From:
Chinese Journal of Organ Transplantation
2023;44(3):167-171
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of parental liver donation on early acute cellular rejection(ACR)after liver transplantation(LT)in children aged under one year.Methods:From January 2018 to January 2021, retrospective review is conducted for clinical data of living donor LT recipients and donors aged under 1 year at Tianjin First Central Hospital.Donor livers are assigned into two groups of paternal donor liver(156 cases)and maternal donor liver(206 cases)according to the source of donor liver, Clinical characteristics and postoperative ACR occurrence of two groups are analyzed.Results:The rates of ACR during early postoperative period is 14.9%(54/362), 20.5%(32/156)in paternal liver donor group and 10.7%(22/206)in maternal liver donor group.There is statistically significant difference(λ 2=6.763, P=0.009).In analysis of gender matching of donor recipients, the rates of ACR is 22.6% in paternal donor group and 10.3% in maternal donor group.There is statistically significant difference(λ 2=5.411, P=0.020).Median time of initial postoperative ACR is 13.00(8.25~20.25)day in paternal liver donor group and 17.00(9.00~28.25)day in maternal donor group.The difference is not statistically significant( P>0.05). ACR is mostly mild-to-moderate in two groups . Conclusions:In living donor LT for children aged under 1 year, the rates of early ACR is lower for maternal donor than that for paternal donor, especially in female recipients.
