Quality-of-life and associated factors after pediatric liver transplantation: based upon CHU9D scale
10.3760/cma.j.cn421203-20220713-00176
- VernacularTitle:基于9维儿童健康效用量表调查结果的儿童肝移植受者生命质量及其影响因素分析
- Author:
Ranjia LIU
1
;
Chen PAN
;
Ye XU
;
Mingxing GUO
;
Xiangli CUI
;
Zhijun ZHU
Author Information
1. 首都医科大学附属北京友谊医院药剂科，北京 100050
- Keywords:
Child;
Liver transplantation;
Quality of life;
Survey research
- From:
Chinese Journal of Organ Transplantation
2023;44(2):102-108
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore health utility value, evaluate health-related quality-of-life(QOL)of pediatric liver transplantation(LT)recipients and examine its influencing factors to provide rationales for related health economic evaluations.Methods:This cross-sectional QOL was conducted through a questionnaire in pediatric LT recipients aged 5-17 years.The interviewees undergoing initial LT from June 2013 to September 2021 were reviewed regularly.Those children and their parents unwilling to participate or failing to understand the contents of questionnaire were excluded.The questionnaire was designed on the basis of Child Health Utility 9D Instrument(CHU9D)and answered online by one of primary caregiver.Chinese score system of CHU9D was employed for converting the responses into health utility values and the influencing factors were analyzed.Univariate analysis was performed by nonparametric tests and multivariate analysis by multiple linear regression model. P<0.05 was deemed as statistically significant. Results:A total of 140 valid questionnaires were obtained.Mean age of pediatric LT recipients was(7.95±2.74)years and mean postoperative time(4.90±2.17)years.Among them, 19 cases had experienced acute rejection and 101(72.1%)cases were living-related LT recipients.CHU9D scale indicated that average health utility value was(0.85±0.14)points.Univariate analysis revealed that age( P=0.008), education level( P<0.001)and primary disease( P=0.010)influenced the postoperative level of QOL.Multivariate analysis indicated that QOL was correlated with education level(behind schedule: 95% CI: -0.146, -0.034, P=0.002; leave of absence: 95% CI: -0.251, -0.068, P=0.001). Conclusions:Health utility of pediatric LT recipients is high with an excellent QOL.Poor QOL is associated with absence from school or dropping out of school.
