Early thrombotic risks and prophylactic anticoagulation after liver transplantation
10.3760/cma.j.cn421203-20220727-00184
- VernacularTitle:肝移植术后早期血栓风险及预防性抗凝研究进展
- Author:
Hongzhao YANG
1
;
Qiushi LIANG
;
Jian YANG
;
Tao LYU
;
Kunlin XIE
;
Jing ZHOU
;
Jiayin YANG
;
Hong WU
Author Information
1. 四川大学华西医院肝移植中心，成都 610041
- Keywords:
Liver transplantation;
Hypercoagulable state;
Thrombus;
Anticoagulation therapy
- From:
Chinese Journal of Organ Transplantation
2023;44(1):53-61
- CountryChina
- Language:Chinese
-
Abstract:
In early stage after liver transplantation(LT), coagulation function of recipients stays in a fragile balance. Affected by a variety of complex mechanisms, blood is usually hypercoagulable. An imbalance between coagulation factors and physiological anticoagulants, elevated level of vWF, an occurrence of fibrinolysis inhibition and dosing of immunosuppressive agents cause a hypercoagulable state in an early stage after LT. Blood hypercoagulability may lead to such thrombotic complications as hepatic artery, portal vein and deep vein thromboses. Some studies have demonstrated that postoperative prophylactic anticoagulation has some effect in reducing the risks of early postoperative thrombosis. However, there is still a great lack of high-quality evidence. This review summarized the latest researches on early coagulation dysfunction, thrombosis and preventive anticoagulation after LT.
