Mortality relevant factors of COVID-19 infection in kidney transplantation recipients: a systematic review and Meta-analysis
10.3760/cma.j.cn421203-20220928-00242
- VernacularTitle:肾移植术后新型冠状病毒感染受者院内死亡影响因素的系统评价与Meta分析
- Author:
Dilixiati DILIYAER
1
;
Kadier KAISAIERJIANG
;
Azhati BAIHETIYA
;
Aizimaiti MIKEREYI
;
Rexiati MULATI
;
Xilipu REYIHAN
Author Information
1. 新疆医科大学第一附属医院泌尿中心，乌鲁木齐 830054
- Keywords:
Kidney transplantation;
COVID-19;
Death;
Meta-analysis
- From:
Chinese Journal of Organ Transplantation
2023;44(1):31-39
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess the evidence for relevant factors associated with mortality in COVID-19 kidney transplantation recipients(KTR) through Meta-analysis.Methods:A complete search of PubMed, Web of Science, Medline, Scopus, Cochrane Library, CNKI and Wanfang Database were performed to search for eligible studies on 18 August 2022.Results:twenty-nine studies involving 7 978 Cases were included in our Meta-analysis.Patients with mean age ≥60 years( OR=1.09, 95% CI: 1.06-1.13), Comorbidities including diabetes mellitus( OR=1.49, 95% CI: 1.26-1.76), cardiovascular disease( OR=1.88, 95% CI: 1.33-2.65), and acute kidney injury( OR=3.46, 95% CI: 1.35-8.89) significantly increased mortality risk.KTR with dyspnea ( OR=2.17, 95% CI: 1.38-3.42), higher Hemoglobin ( OR=1.09, 95% CI: 1.00-1.19), Use of mycophenolic ( OR=1.18, 95% CI: 1.02-1.37) and Antibiotics( OR=7.26, 95% CI: 2.11-25.07) at presentation were at higher mortality risk, while diarrhea( OR=0.57, 95% CI: 0.34-0.96) and higher eGFR( OR=0.95, 95% CI: 0.92-0.98) decreased the risk.Overall in-hospital mortality in COVID-19 KTR was 19%, 95% CI: 15%-23%. Conclusions:Our systematic review and -analysis results suggest that overall in-hospital mortality in COVID-19 KTR declined progressively over time.KTR with these risk factors should receive more intensive monitoring and early therapeutic interventions to optimize health outcomes.
