Distribution characteristics and risk factors of fungal infection after liver transplantation from deceased donation
10.3760/cma.j.cn421203-2022-0830-00219
- VernacularTitle:死亡捐献供肝移植术后真菌感染分布特征及危险因素分析
- Author:
Dong WANG
1
;
Shun ZHOU
;
Yong WANG
;
Changxian LI
;
Xiangcheng LI
Author Information
1. 南京医科大学第一附属医院肝胆中心，南京 210029
- Keywords:
Liver transplantation;
Deceased donation;
Fungi;
Risk factors
- From:
Chinese Journal of Organ Transplantation
2022;43(11):670-674
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the pathogenic characteristics and related risk factors of fungal infection after liver transplantation(LT)from deceased donation and provide rationales for formulating optimal control strategies.Methods:From February 2019 to September 2020, clinical data were retrospectively reviewed for 187 recipients after LT from deceased donation.Univariate and multiple Logistic regression analyses were performed for determining the independent risk factors of postoperative fungal infection.Results:Among 187 LT cases, 26 cases had postoperative fungal infection with a mortality rate of 46.2%(12/26). Lung was the most common fungal infection site, accounting for 80.8%(21/26). The most common pathogenic bacteria of fungal infection were Candida albicans, accounting for 53.3%(16/30). Multiple Logistic regression analysis indicated that operative duration ≥8 h( OR=3.610, 95% CI: 1.079-12.081, P=0.037), re-operation( OR=39.234, 95% CI: 3.512-438.258, P=0.003)and intensive care unit(ICU)retention time ≥7 d( OR=10.070, 95% CI: 3.480-29.140, P=0.002)were independent risk factors of postoperative fungal infection. Conclusions:Postoperative fungal infection is a serious threat to the prognosis of recipients of LT from deceased donation.Minimizing operative duration on the basis of ensuring quality of surgery, strictly grasping the indications for re-operation and transferring out of ICU in early postoperative period may help to lower the risks of fungal infection after LT from deceased donation.
