Efficacy and safety of rivaroxaban in different doses for the treatment of isolated distal deep vein thrombosis
10.3760/cma.j.cn113855-20230116-00024
- VernacularTitle:利伐沙班治疗孤立远端深静脉血栓的回顾性研究
- Author:
Qing WANG
1
;
Baoyan WANG
;
Run JI
;
Ye JI
;
Zhipeng CHEN
;
Tong QIAO
Author Information
1. 南京中医药大学鼓楼临床医学院血管外科，南京 210008
- Keywords:
Deep vein thrombosis;
Drug dosage calculation;
Rivaroxaban;
Anticoagulation duration
- From:
Chinese Journal of General Surgery
2023;38(8):611-615
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy and safety of of rivaroxaban for different doses in the treatment of isolated distal deep vein thrombosis.Methods:The clinical data of 853 patients of isolated distal deep vein thrombosis attending Nanjing Drum Tower Hospital from Jan 2018 to Dec 2020 was retrospectively analyzed.Results:Thrombotic recurrence rate increased with increasing follow-up in the standard and low dose groups, and it was significantly lower in the standard dose group than in the low dose group (HR=0.44, 95% CI: 0.25-0.78, P=0.005) with most thrombosis occurring within the first year of follow-up. There was no statistical difference between the two groups in terms of major bleeding events (HR=1.70,95%CI 0.56-5.14, P=0.530) and the incidence of clinically relevant non-major bleeding events was significantly higher in the standard dose group than in the low dose group (HR=2.36, 95%CI 1.26-4.44, P=0.020). Subgroup analysis on anticoagulation duration found when anticoagulation duration was longer than 1.5 months, the risk of thrombosis was lower in the standard dose group than the low dose group (1.5-3 months:HR=0.11, 95%CI 0.01-0.87, >3 months: HR=0.19, 95%CI 0.04-0.95), there was an interaction between anticoagulation duration and dose ( P=0.007). Conclusions:Based on the risk of thrombosis recurrence and bleeding events, the standard dose of rivaroxaban (20 mg qd) is recommended for patients with isolated distal deep vein thrombosis, and the anticoagulant duration should be maintained for 1.5 months or more.
