Clinicopathological features and prognostic analysis of primary duodenal adenocarcinoma
10.3760/cma.j.cn113855-20230429-00216
- VernacularTitle:原发性十二指肠腺癌的临床病理特征及预后分析
- Author:
Wenjie WANG
1
;
Junling ZHANG
;
Hang ZHENG
;
Yingchao WU
;
Yong JIANG
;
Pengyuan WANG
;
Guowei CHEN
;
Tao WU
;
Tianye LIU
;
Jixin ZHANG
;
Xin WANG
Author Information
1. 北京大学第一医院胃肠外科，北京 100034
- Keywords:
Duodenal neoplasms;
Adenocarcinoma;
Pathology, clinical;
Prognosis
- From:
Chinese Journal of General Surgery
2023;38(8):582-588
- CountryChina
- Language:Chinese
-
Abstract:
Objective:By analyzing the clinical data of patients with primary duodenal adenocarcinoma (PDA), the risk factors affecting the postoperative prognosis of PDA patients were discussed.Methods:The clinical data of 191 patients diagnosed with PDA in Peking University First Hospital from Jan 2009 to Dec 2022 were collected. The survival rate was calculated and the survival curve was plotted by Kaplan-Meier method. Univariate analysis was performed by Log-Rank test, and multivariate analysis was performed by COX proportional hazards regression model to obtain independent risk factors.Results:The median age of onset in patients with PDA is 65 years old, and the most common symptoms are abdominal pain and abdominal distension. Prognostic analysis showed that the survival rates at 1, 3 and 5 years were 73.8%, 44.6%, and 23.0%. The analysis of Cox risk proportional regression model showed that preoperative CA19-9 level, depth of tumor invasion, degree of differentiation, TNM stage, and surgical mode were independent risk factors for the prognosis of PDA (all P<0.01). Conclusion:The overall incidence of PDA is low, but the prognosis is rather poor. Multvariable factors are associated with its prognosis and surgery is still the mainstay for hope of cure.
