Clinical characteristics and prognosis of duodenal neuroendocrine neoplasms
10.3760/cma.j.cn113855-20221107-00691
- VernacularTitle:十二指肠神经内分泌肿瘤的临床病理特征及预后分析
- Author:
Xinyu ZENG
1
;
Chengguo LI
;
Jianbo LYU
;
Gan MAO
;
Liwu ZENG
;
Yuqiang DU
;
Zhenyu LIN
;
Peng ZHANG
;
Rong LIN
;
Kailin CAI
;
Kaixiong TAO
Author Information
1. 华中科技大学同济医学院附属协和医院胃肠外科，武汉 430022
- Keywords:
Neuroendocrine tumors;
Duodenal neoplasms;
Prognosis
- From:
Chinese Journal of General Surgery
2023;38(6):418-422
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical characteristics and prognosis of duodenal neuroendocrine neoplasms.Methods:The clinical data of 35 patients with duodenal neuroendocrine neoplasms admitted to Union Hospital, Tongji Medical College, Huazhong University of Science & Technology from Jan 2012 to Dec 2021 were retrospectively analyzed. The differences of clinical characteristics between periampullary and non-periampullary duodenal neuroendocrine neoplasms were analyzed. Kaplan-Meier curve was used for survival analysis, and the clinical factors affecting the prognosis were analyzed.Results:Of the 35 patients, 30 underwent tumor resection, 7 (23%) developed different degree of complications after operation and were improved and discharged after intervention. A total of 5 patients died during the follow-up period. Only 1 of 30 patients who underwent tumor resection died 30 months after operation due to disease progression, and the others had no recurrence or metastasis. Univariate analysis showed that tumor size, tumor grade, and tumor location were associated with the prognosis of patients (all P<0.05), and multivariate analysis showed that patients with tumors located.Away from the ampulla had a significantly better prognosis than those located around the duodenal ampulla ( P<0.01). Conclusions:Patients with duodenal neuroendocrine neoplasms have a good prognosis after complete resection; patients with duodenal neuroendocrine neoplasms located around the ampulla of Vater have a relatively poor prognosis compared with those away from the area of ampulla.
