Clinicopathological comparison of intrahepatic cholangiocarcinoma with and without viral hepatitis
10.3760/cma.j.cn113855-20220831-00535
- VernacularTitle:有无病毒性肝炎的肝内胆管癌的临床病理特征对比分析
- Author:
Sen YANG
1
;
Yanbing LIU
;
Pan WU
;
Shuai YAN
;
Feilong TAN
;
Zhongyuan ZHAO
;
Yiyang YAN
;
Xueliang YUE
;
Hongshan LIU
Author Information
1. 河南省人民医院肝胆胰外科 郑州大学人民医院 河南大学临床医学院，郑州 450003
- Keywords:
Cholangiocarcinoma;
Hepatitis, viral, human;
Clinicopathology
- From:
Chinese Journal of General Surgery
2023;38(4):292-296
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the different clinicopathological features of intrahepatic cholangiocarcinoma with and without viral hepatitis.Methods:The clinicopathological data of 79 intrahepatic cholangiocarcinoma cases from Mar 2012 to Sep 2018 at Henan Provincial People's Hospital were retrospectively analyzed.Results:Twenty-five of the 79 patients with intrahepatic cholangiocarcinoma were accompanied by viral hepatitis. Those with viral hepatitis had a lower mean age at onset than those without [(53±11) years vs. (60±11) years, P=0.011], higher proportion of male patients (80% vs. 52%, P=0.017), higher AFP positive rate (40% vs. 19%, P=0.041), lower CA19-9 positive rate (48% vs. 72%, P=0.036), tend to occur in the right liver lobe (76% vs. 44%, P=0.009), a lower rate of bile duct invasion (16% vs. 41%, P=0.03), and were more likely to be mass type (mass type proportion 96% vs. 72%, P=0.032). Conclusions:Viral hepatitis is common in intrahepatic cholangiocarcinoma. Intrahepatic cholangiocarcinoma with and without viral hepatitis differ in clinicopathology. Intrahepatic cholangiocarcinoma with viral hepatitis is more likely to have the characteristics of hepatocellular carcinoma, while intrahepatic cholangiocarcinoma without viral hepatitis is more likely to have the characteristics of cholangiocarcinoma.
