Prognostic value of lymphocyte subsets in gastric cancer with different tumor infiltration patterns
10.3760/cma.j.cn113855-20220630-00426
- VernacularTitle:淋巴细胞亚群对于不同肿瘤浸润模式胃癌的预后价值
- Author:
Hao WANG
1
;
Xin YIN
;
Xibo WANG
;
Zhanfei LU
;
Jiaqi ZHANG
;
Junpeng WU
;
Yimin WANG
;
Yingwei XUE
Author Information
1. 哈尔滨医科大学附属肿瘤医院胃肠外科，哈尔滨 150081
- Keywords:
Stomach neoplasms;
Lymphocyte subsets;
Prognosis
- From:
Chinese Journal of General Surgery
2023;38(4):280-286
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To probe into the potential prognostic value of lymphocyte subsets in gastric cancer.Methods:This study included patients who underwent radical gastrectomy for gastric cancer from Aug 2014 to Dec 2016. The immunological differences was analyzed in different infiltration patterns. The overall survival of patients was analyzed by Kaplan-Meier method and Log-rank test. COX regression was performed to assess independent prognostic factors of the patients, and finally constructed nomogram.Results:The median number of peripheral CD4 and CD19 cells in infiltration pattern c was 750 (94-2 504) cells/μl and 186 (17-820) cells/μl; the median number of peripheral CD4 and CD19 cells in infiltration pattern a was 802 (203-2 071) cells/μl and 213 (5-948) cells/μl, the number of peripheral CD4,CD19 cells in infiltration pattern c was lower than that in infiltration pattern a, with statistically significant differences (CD4: Z=-3.061, P=0.002; CD19: Z=-2.016 , P=0.044). CD19 lymphocytes ( P=0.023) were associated with infiltration pattern a, CD8 lymphocytes ( P=0.027) were associated with infiltration pattern b, and CD4 lymphocytes ( P=0.026) were independent risk factors associated with the prognosis of infiltration pattern c. A nomogram can be constructed to evaluate the prognosis of patients. Conclusion:There are differences in the number of peripheral lymphocyte subsets in patients with different INF types. A nomogram can be constructed from lymphocyte subsets and clinicopathological features to assess patient prognosis.
