Prognostic value of the number and anatomical distribution of tumor deposits in patients with gastric cancer without lymph node metastasis
10.3760/cma.j.cn113855-20221029-00665
- VernacularTitle:癌结节数目及分布在淋巴结阴性胃癌患者中的预后价值
- Author:
Ran XU
1
;
Xin WU
;
Huaping XU
;
Jun ZHAO
;
Yisheng ZHANG
;
Ke CHEN
;
Zhengguang WANG
Author Information
1. 皖南医学院弋矶山医院普外科，芜湖 241001
- Keywords:
Stomach neoplasms;
Lymph node;
Tumor deposits;
Prognosis
- From:
Chinese Journal of General Surgery
2023;38(4):275-279
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the prognostic value of tumor deposits (TD) by number and anatomical distribution in gastric cancer (GC) patients without lymph node metastasis.Methods:From Aug 2012 to Aug 2018 all 91 GC patients undergoing radical gastrectomy and without nodal metastasis at Yijishan Hospital of Wannan Medical College were enrolled in this study. Patients were divided into L1, L2, and L3 groups according to the number of TD and into Q1 and Q2 groups according to the anatomical regions of the TD.Results:The 3-year overall survival (OS) rates of groups L1, L2, and L3 were 58.9%, 52.1%, and 31.5%, respectively ( χ2=9.769, P=0.008). The 3-year OS rates of groups Q1 and Q2 were 58.9% and 7.1% ( χ2=46.310, P<0.001). The number of TD, their distribution, neural invasion, vascular invasion, tumor size, and pT stage were all related to prognosis by univariate analysis (all P<0.05). Tumor size>4 cm ( HR=2.460, 95% CI:1.307-4.629, P=0.005), distribution of TD (non-perigastric)( HR=3.959, 95% CI:2.077-7.545, P<0.001), neural invasion ( HR=4.299,95% CI:1.953-9.461, P<0.001), and pT 4 stage ( HR=2.283, 95% CI:1.250-4.171, P=0.007) were independent risk factors for prognosis by multivariate analysis. Conclusion:The distribution of TD (non-perigastric) is an independent risk factor for poor prognosis in gastric cancer patients after radical gastrectomy and with negative lymph node metastasis.
