The significance of tumor deposits in prognosis and lymph node staging in gastric cancer patients
10.3760/cma.j.cn113855-20221019-00632
- VernacularTitle:癌结节对胃癌患者预后及淋巴结分期的影响及其意义
- Author:
Jiaxin YUAN
1
;
Bibo TAN
;
Yong LI
;
Liqiao FAN
;
Qun ZHAO
;
Qingwei LIU
;
Wenbo LIU
;
Yijie ZHAO
;
Zaibo ZHANG
;
Jiaxiang CUI
Author Information
1. 河北医科大学第四医院外三科，石家庄 050011
- Keywords:
Stomach neoplasms;
Prognosis;
Tumor staging;
Tumor deposits
- From:
Chinese Journal of General Surgery
2023;38(4):269-274
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of tumor deposits on the prognosis and lymph node staging in patients with gastric cancer.Methods:The clinicopathological data of 907 patients with gastric cancer admitted to the Fourth Hospital of Hebei Medical University from Jan to Dec 2016 were retrospectively analyzed. According to the pathological diagnosis, the patients were divided into tumor deposits positive group (121 cases) and tumor deposits negative group (786 cases), and the relationship between tumor deposits and clinicopathological features and prognosis was analyzed.Results:Tumor deposits were found in 121 patients among 907 cases. Univariate analysis showed that tumor deposits were correlated with pT stage, pN stage, pTNM stage, tumor diameter, nerve invasion and vascular invasion (all P<0.05). Multivariate analysis showed that pT stage ( P<0.001), pN stage ( P=0.002), pTNM stage ( P=0.001), tumor diameter ( P=0.033),nerve invasion ( P=0.017), vascular invasion ( P=0.011) were the independent influencing factors of positive tumor deposits. The prognosis of patients with tumor deposits was worse than those without ( χ2=77.869, P<0.001). By univariate analysis, age, tumor location, size, pT stage, pN stage, pTNM stage, tumor thrombus, nerve invasion, tumor deposits and number affected prognosis (all P<0.05). Multivariate analysis showed that age, pT stage, pN stage, pTNM stage, nerve invasion, vascular invasion and the number of tumor deposits were independent prognostic factors (all P<0.05). By stratified analysis tumor deposits were found to have statistical difference in N0~N3a stage (all P<0.05). Conclusion:Tumor deposits is an independent risk factor affecting the prognosis of gastric cancer patients.
