Analysis of factors associated with postoperative acute kidney injury in patients with colorectal cancer
10.3760/cma.j.cn113855-20220810-00508
- VernacularTitle:结直肠癌患者术后急性肾损伤的相关因素分析
- Author:
Liu LI
1
;
Xiaochen WAN
;
Yonglei ZHANG
;
Minghai ZHAO
;
Jinjun REN
;
Yongchao ZHANG
Author Information
1. 郑州大学附属肿瘤医院(河南省肿瘤医院)普外科,郑州 450008
- Keywords:
Colorectal neoplasms;
Acute kidney injury;
Risk factors
- From:
Chinese Journal of General Surgery
2023;38(3):202-206
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate factors associated with acute kidney injury(AKI) in postoperative colorectal cancer patients.Methods:The clinical data of 376 colorectal carcinoma (CRC) patients at Department of General Surgery, Affiliated Cancer Hospital of Zhengzhou University from Jan 2018 to Jun 2021 were retrospectively analyzed. Patients were divided into acute kidney injury (AKI) ( n=29) and non-AKI groups ( n=347). The demographic information, perioperative status, laboratory results and other relevant data of the two groups were compared . Binary logistic regression was used to analyze the independent risk factors for postoperative AKI. Results:Twenty-nine CRC patients (7.7%) had postoperative AKI. Binary Logistic regression analysis showed that preoperative hypertension ( OR=3.487, 95% CI: 1.081-11.251, P=0.037), anemia ( OR=3.158, 95% CI: 1.114-8.953, P=0.031), inadequate intraoperative crystalloid infusion ( OR=0.998, 95% CI: 0.997-0.999, P=0.007), low intraoperative mean arterial pressure ( OR=0.915, 95% CI: 0.863-0.970, P=0.003) and moderate to severe postoperative decline in hemoglobin levels ( OR=4.105, 95% CI: 1.487-11.335, P=0.006) were independent risk factors. Conclusion:Preoperative hypertension, anemia, inadequate intraoperative crystalloid infusion, low intraoperative mean arterial pressure, and moderate to severe postoperative decline in hemoglobin levels were independent risk factors for AKI development in colorectal cancer patients.