Indocyanine green and nanocarbon lymph node tracing in laparoscopic radical resection for right colon cancer
10.3760/cma.j.cn113855-20221008-00602
- VernacularTitle:吲哚菁绿与纳米炭淋巴结示踪技术在腹腔镜右半结肠癌根治术中的应用
- Author:
Yankai ZHANG
1
;
Yichao YAN
;
Ning NING
Author Information
1. 北京大学国际医院胃肠外科，北京 102206
- Keywords:
Colonic neoplasms;
Lymph nodes;
Indocyanine green;
Nanocarbon
- From:
Chinese Journal of General Surgery
2023;38(3):167-172
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the lymph node tracing of indocyanine green (ICG) and nanocarbon in laparoscopic right hemicolectomy.Methods:Fifty-two patients with right colon cancer were randomly divided into two groups: ICG group and nanocarbon group at Peking University International Hospital between Oct 2020 and Jul 2022. Sentinel lymph node (SLN) mapping and standard oncologic resection was performed. The micrometastasis was to detect when the routine SLN pathological test was negative.Results:In ICG group, the detection rate of SLN was 100%, the sensitivity was 93%, the false negative rate was 7%, and the accuracy was 96%,which were better than nanocarbon group (92%,57%,43%,77%). The number of SLN and positive SLN detected in ICG group were significantly higher than nanocarbon group [(3.2±0.7) vs. (2.6±1.1), t=4.424, P=0.020; (1.2±1.2) vs.(0.5±0.8), t=15.176, P=0.013]. The SLN biopsy accuracy of patients with BMI ≥24 kg/m 2 and tumor diameter ≥3 cm in ICG group was significantly higher than nanocarbon group (90% vs. 44%, χ 2=7.935, P=0.005; 90% vs.57%, χ 2=4.309, P=0.038). The detection rate of micrometastasis in SLN of ICG group was significantly different from nanocarbon group (35% vs. 15%, χ 2=5.853, P=0.016). Conclusion:ICG fluorescence imaging is superior to nanocarbon in SLN biopsy during laparoscopic radical right hemicolectomy, especially when patients' BMI ≥24 kg/m 2 and tumor diameter ≥3 cm.
