Early diagnosis of anastomotic leakage after anterior resection for rectal carcinoma
10.3760/cma.j.cn113855-20220728-00480
- VernacularTitle:直肠癌前切除术后吻合口漏的早期诊断研究
- Author:
Yansheng ZHANG
1
;
Pengjin SUN
;
Zengqiang YANG
;
Ming XU
;
Weiqiang WU
;
Feng GAO
Author Information
1. 中国人民解放军联勤保障部队第940医院结直肠肛门外科，兰州 730050
- Keywords:
Rectal neoplasms;
Anastomotic leakage;
Rectectomy;
Diagnosis
- From:
Chinese Journal of General Surgery
2023;38(2):81-85
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To search for valuable laboratory indexes of early diagnosis of anastomotic leakage after anterior resection for rectal carcinoma.Methods:From Sep 2017 to Jan 2019, 128 patients with colorectal cancer underwent anterior rectal resection at the Department of Colorectal & Anal Surgery, the 940 Hospital of the Joint Logistics Support Force.Results:Anastomotic leakage occurred in 16 of 128 patients (12.5%). Definite diagnosis of anastomotic leakage was made on between 2nd and 9th day, postopera tively averagign (6.13±2.00) days. Tumor location was a risk factor for anastomotic leakage with the incidence significantly lower when the distance from the lower edge of the tumor to the anal margin >7 cm than when the distance ≤7 cm ( χ 2=6.022, P=0.014). The percentage of increase in peripheral blood leukocytes, neutrophils, serum interleukin-6, C-reactive protein and procalcitonin in patients 3-5 days after surgery significantly related to the occurrence of anastomotic leakage (all P<0.05). The area under the working characteristic curve of the subjects with the percentage of C-reactive protein, procalcitonin, interleukin-6, leukocytes and neutrophils from the 3rd to the 5th day after operation was greater than 0.5. Conclusion:C-reactive protein, procalcitonin, interleukin-6, leukocyte and neutrophil percentage are risk factors predicting anastomotic leakage after anterior resection of rectal cancer.
