CT features of gastric stromal tumors in predicting Ki-67 index expression
10.3760/cma.j.cn113855-20220316-00163
- VernacularTitle:胃间质瘤的CT特征预测Ki-67表达水平的可行性研究
- Author:
Sikai WANG
1
;
Guangyan SI
;
Mingliang WANG
;
Haixing WANG
;
Bin YANG
;
Mengsu ZENG
Author Information
1. 西南医科大学附属中医医院放射科，泸州 646000
- Keywords:
Gastrointestinal stromal tumors;
Tomography, X-ray compute;
Ki-67 index
- From:
Chinese Journal of General Surgery
2023;38(1):44-49
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the feasibility of multi-slice spiral CT (MSCT) imaging feature of gastric stromal tumor (GST) in evaluating Ki-67 index expression .Methods:The clinical and CT imaging data of 501 patients with GST confirmed by surgery and pathology were retrospectively studied in Zhongshan Hospital affiliated to Fudan University and the Affiliated TCM Hospital of Southwest Medical University from Nov 2014 to Nov 2021. By immunohistochemical results, tumors were divided into Ki-67 low expression group (Ki-67≤6%, 335 lesions) and high expression group (Ki-67>6%, 168 lesions). Multivariate logistic regression analysis was conducted.Results:Between the two groups,there were statistical differences in the longest and shortest diameter of tumor, CT value on venous phase, CT attenuation value ( Z=4.80, 4.91, 3.21, 3.29, all P<0.01) and tumor location,morphology, necrosis, ulcer, feeding artery, vascular enhancement, positive fat sign around disease, gastrointestinal bleeding ( χ2=10.77, 13.49, 8.59, 22.87, 7.59, 7.23, 7.76, 8.58, all P<0.05). Tumor ulceration positive ( OR=1.88, 95%CI: 1.17-3.03) was independent risk factor of Ki-67 high expression ( P=0.009). Gastric antrum was used as the reference for tumor location, cardia ( OR=5.41, 95% CI:1.25-23.46) was independent risk factor of Ki-67 high expression ( P=0.024). Conclusion:MSCT has a definite predictive value for the expression in Ki-67 index of GST cases.
