Risk factors for early recurrence of patients with single large hepatocellular carcinoma after hepatectomy
10.3760/cma.j.cn113855-20220621-00404
- VernacularTitle:单发大肝癌术后早期复发危险因素分析
- Author:
Yingpeng YE
1
;
Yong YANG
;
Xingchen CAI
;
Hongda ZHU
;
Caide LU
;
Jiongze FANG
Author Information
1. 宁波大学附属李惠利医院肝胆胰外科，宁波 315041
- Keywords:
Carcinoma, hepatocellular;
Risk factors;
Radical resection;
Recurrence
- From:
Chinese Journal of General Surgery
2023;38(1):1-6
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the risk factors for postoperative early recurrence of patients with single large hepatocellular carcinoma (HCC) (tumor diameter≥5cm).Methods:Clinical data of 135 single large HCC patients who underwent radical resection from Jan 2015 to Sep 2020 in Ningbo Medical Centre Lihuili Hospital were analyzed.Results:Seventy-five HCC patients suffered recurrence,among those 42 patients had early recurrence(within 12 months). Multivariate analysis showed that alpha-fetoprotein (AFP)≥400 ng/ml ( OR=3.510,95% CI: 1.528-8.064; P=0.003) and tumor microvascular invasion (MVI) ( OR=2.769,95% CI: 1.143-6.706; P=0.024) were independent risk factors for early recurrence of single large hepatocellular carcinoma. Survival analysis showed that early recurrence risk factors significantly reduced recurrence free survival (RFS)(AFP≥400 ng/ml, χ 2=23.038, P<0.001; MVI positive , χ 2=10.554, P=0.001) and overall survival (OS) (AFP≥400 ng/ml, χ 2=14.336, P<0.001; MVI positive, χ 2=10.481, P=0.001) in single large hepatocellular carcinoma patients. Conclusion:AFP≥400 ng/ml and MVI positive are independent risk factors for postoperative early recurrence in single large hepatocellular carcinoma patients.
