Survival outcomes of patients with intrahepatic cholangiocarcinoma undergoing surgical resection
10.3760/cma.j.cn113855-20220727-00479
- VernacularTitle:肝内胆管细胞癌外科治疗疗效分析
- Author:
Ruolin WU
1
;
Changjiang ZHANG
;
Enqiang GUO
;
Guanghou CHEN
;
Songbing LIU
;
Hongyu WU
;
Xiaojun YU
;
Fan HUANG
;
Guobin WANG
;
Hongchuan ZHAO
;
Xiaoping GENG
Author Information
1. 安徽医科大学第一附属医院普外科，合肥 230022
- Keywords:
Bile ducts,intrahepatic;
Cholangiocarcinoma;
Surgical resection;
Tumor recurrence;
Disease-free survival;
Overall survival
- From:
Chinese Journal of General Surgery
2022;37(12):896-902
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical outcomes of patients with intrahepatic cholangiocarcinoma (ICC) undergoing surgical resection.Methods:Patients who undergoing radical surgical resection for ICC from Jan 2015 to Apr 2021 at the Department of General Surgery, the First Affiliated Hospital of Anhui Medical University were included in this retrospective cohort study.Results:There were 67 patients in the final analysis, The median follow-up duration was 14 months (range: 1-60 months). Firty three patients (79.1%) had tumor recurrence, 52 patients (77.6%) died, Among them, 49 patients (73.1%) died from tumor recurrence. The 1-、2-、and 3-year accumulated disease-free and overall survival rate were 35.6%, 19.6%, 16.8% and 53.7%, 32.4%, 20.8%. respectively. The overall survival rate of the group without microvascular invasion was significantly better than those of the group with microvascular invasion ( χ2=5.916, P=0.015). CA19-9≥1 000 U/ml was the only independent risk factor for the disease-free survival. CA19-9≥1 000 U/ml、blood loss≥600 ml、microvascular invasion and tumor recurrence were the independent risk factors for the overall survival. Conclusion:For ICC patients with single tumor, when the tumor diameter is less than 5 cm and has no microvascular invasion, surgical resection is recommended, and a satisfactory prognosis could be achieved.
