Epitope spreading in autoimmune bullous diseases
- VernacularTitle:自身免疫性疱病的表位扩展现象
- Author:
Ying SHAN
1
;
Xiaotong CHANG
;
Yagang ZUO
Author Information
- Keywords: Pemphigoid, bullous; Pemphigus; Epitopes; Autoimmune bullous diseases; Epitope spreading; Psoriasis
- From: Chinese Journal of Dermatology 2023;56(7):702-705
- CountryChina
- Language:Chinese
- Abstract: Epitope spreading often occurs in patients with autoimmune bullous diseases (ABDs), resulting in exposure of more antigenic epitopes, aggravation or transformation of pre-existing diseases, or concurrence of other diseases. With the increase in the immunological evidence for epitope spreading, more and more scholars have realized that epitope spreading plays an important role in the development of ABDs. This review introduces the phenomenon of epitope spreading in ABDs from 4 aspects, including the concurrence of or transformation between different types of pemphigoid, different types of pemphigus, pemphigus and pemphigoid, as well as between ABDs and other skin diseases.
