Biomarkers related to the treatment of melanoma with immune checkpoint inhibitors
- VernacularTitle:黑素瘤免疫检查点抑制剂治疗相关的生物标志物研究进展
- Author:
Yongting YANG
1
;
Tingting LI
;
Xiaojing KANG
Author Information
- Keywords: Nevi and melanoma; Tumor microenvironment; Immune checkpoint inhibitors; Tumor mutation burden; Peripheral blood biomarkers; Gut microbiota
- From: Chinese Journal of Dermatology 2023;56(3):278-283
- CountryChina
- Language:Chinese
- Abstract: Recently, great breakthroughs have been made in the treatment of melanoma with immune checkpoint inhibitors. However, only a small proportion of patients show a long-lasting response to immunotherapy, and risks of immune-related adverse events and drug resistance have been also increasing along with the emergence of combination treatment. This review summarizes biomarkers related to the efficacy of immune checkpoint inhibitors in the treatment of melanoma, aiming to predict and screen out patients who may benefit from immunotherapy, guide individualized clinical treatment, and reduce the occurrence of drug resistance and adverse reactions.
