Clinical features of non-cirrhotic portal hypertension in patients with common variable immunodeficiency
10.3760/cma.j.cn112138-20220819-00610
- VernacularTitle:普通变异型免疫缺陷病并发非肝硬化性门脉高压症6例临床资料分析
- Author:
Juan WU
1
;
Xinxin HAN
;
Hong DI
;
Yue YIN
;
Yingdong HAN
;
Yu WANG
;
Yun ZHANG
;
Xuejun ZENG
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院全科医学科（普通内科）疑难重症及罕见病国家重点实验室，北京 100730
- Keywords:
Common variant immunodeficiency;
Hypertension, portal;
Non-cirrhosis
- From:
Chinese Journal of Internal Medicine
2023;62(8):1007-1011
- CountryChina
- Language:Chinese
-
Abstract:
We wished to summarize the clinical features of common variable immunodeficiency (CVID) complicated by non-cirrhotic portal hypertension (NCPH) and to deepen our understanding of it. The case data of CVID complicated with NCPH admitted to Peking Union Medical College Hospital from January 1983 to May 2021 were analyzed retrospectively to summarize their clinical characteristics. Six patients with CVID combined with NCPH (three of each sex; 16-45 years) were assessed. Four patients had portal hypertension. All patients had anemia, splenomegaly, a normal serum level of albumin and transaminases, and possibly increased levels of alkaline phosphatase and gamma-glutamyl transpeptidase. Two patients were diagnosed with esophagogastric fundic varices by gastroscopy. Two patients underwent splenectomy (which improved hematologic abnormalities partially). Four patients had autoimmune disease. Two cases were diagnosed with nodular regenerative hyperplasia (NRH) upon liver biopsy. Six patients were administered intravenous immunoglobulin-G (0.4-0.6 g/kg bodyweight) once every 3-4 weeks as basic therapy. Often, CVID complicated with NCPH has: (1) The manifestations of portal hypertension as the primary symptom. (2) Autoimmune-related manifestations. Imaging can provide important diagnostic clues. The etiology may be related to hepatic NRH and splenomegaly due to recurrent infections.
