Distribution characteristics of plasma renin concentration in patients with aldosterone-producing adenoma
10.3760/cma.j.cn112138-20230105-00007
- VernacularTitle:醛固酮瘤患者的血浆肾素水平及分布
- Author:
Jiayu LIANG
1
;
Ying JING
;
Hang SHEN
;
Xiangjun CHEN
;
Wenjin LUO
;
Ying SONG
;
Yue WANG
;
Jinbo HU
;
Shumin YANG
;
Feifei WU
;
Qifu LI
Author Information
1. 重庆医科大学附属第一医院内分泌科，重庆 400016
- Keywords:
Hyperaldosteronism;
Renin;
Primary aldosteronism;
Aldosterone-producing adenoma
- From:
Chinese Journal of Internal Medicine
2023;62(8):972-978
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the distribution characteristics of plasma renin concentration (PRC) in patients with aldosterone-producing adenoma (APA) and its impact on diagnosis.Methods:In this retrospective case series, clinical data from 200 patients with APA (80 men and 120 women; mean age 45.6 years) in the First Affiliated Hospital of Chongqing Medical University from November 2013 to January 2022 were evaluated. PRC was determined by automated chemiluminescence immunoassay. The distribution characteristics of PRC were analyzed, and 8.2 mU/L was used as the low renin cutoff to evaluate whether renin was suppressed.Results:The median PRC was 1.6 mU/L (range, 0.4-41.5 mU/L). There were 116 patients with APA with PRC of ≤2 mU/L, 41 patients with 28.2 mU/L) in 8.0% (16/200) of the patients with APA. And PRC was not suppressed in 2.5% (5/200) of the patients with APA, resulting in a primary aldosteronism negative screening outcome.Conclusions:Although most patients with APA have low PRC, there are a small number (8%) of patients whose PRC has not been fully suppressed, which can lead to missed diagnoses during primary aldosteronism screening. While primary aldosteronism is highly suspected, further investigations are required to determine the diagnosis, even if PRC is not fully suppressed at screening.
