In-Vivo Proton Magnetic Resonance Spectroscopy of 2-Hydroxyglutarate in Isocitrate Dehydrogenase-Mutated Gliomas: A Technical Review for Neuroradiologists.
10.3348/kjr.2016.17.5.620
- Author:
Hyeonjin KIM
1
;
Sungjin KIM
;
Hyeong Hun LEE
;
Hwon HEO
Author Information
1. Department of Radiology, Seoul National University Hospital, Seoul 03080, Korea. hyeonjinkim@snu.ac.kr
- Publication Type:Review
- Keywords:
Proton;
Magnetic resonance spectroscopy;
MRS;
Isocitrate dehydrogenase;
2-hydroxyglutarate;
Glioma;
Mutation
- MeSH:
Biochemistry;
Diagnosis;
Glioma*;
Isocitrate Dehydrogenase;
Magnetic Resonance Spectroscopy;
Proton Magnetic Resonance Spectroscopy*;
Protons*
- From:Korean Journal of Radiology
2016;17(5):620-632
- CountryRepublic of Korea
- Language:English
-
Abstract:
The diagnostic and prognostic potential of an onco-metabolite, 2-hydroxyglutarate (2HG) as a proton magnetic resonance spectroscopy (1H-MRS) detectable biomarker of the isocitrate dehydrogenase (IDH)-mutated (IDH-MT) gliomas has drawn attention of neuroradiologists recently. However, due to severe spectral overlap with background signals, quantification of 2HG can be very challenging. In this technical review for neuroradiologists, first, the biochemistry of 2HG and its significance in the diagnosis of IDH-MT gliomas are summarized. Secondly, various 1H-MRS methods used in the previous studies are outlined. Finally, wereview previous in vivo studies, and discuss the current status of 1H-MRS in the diagnosis of IDH-MT gliomas.
