Prevalence of albuminuria and its association with cardiovascular diseases in Chinese residents aged over 35 years
10.3760/cma.j.cn112138-20220328-00214
- VernacularTitle:中国35岁以上居民白蛋白尿流行状况及心血管疾病风险分析
- Author:
Runqing GU
1
;
Congyi ZHENG
;
Linfeng ZHANG
;
Zuo CHEN
;
Xin WANG
;
Xue CAO
;
Yixin TIAN
;
Lu CHEN
;
Haoqi ZHOU
;
Chen CHEN
;
Zhen HU
;
Yuxin SONG
;
Lan SHAO
;
Ye TIAN
;
Zengwu WANG
Author Information
1. 中国医学科学院北京协和医学院群医学及公共卫生学院，北京 100730
- Keywords:
Cardiovascular diseases;
Albuminuria;
Prevalence;
Urinary albumin to creatinine ratio
- From:
Chinese Journal of Internal Medicine
2023;62(3):290-296
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the prevalence of albuminuria in Chinese residents aged >35 years and its potential association with cardiovascular disease (CVD).Methods:A total of 34 647 Chinese subjects aged ≥35 years were selected by stratified multi-stage random sampling from 2012 to 2015. Data were collected through questionnaires, physical examinations, and laboratory tests. Albuminuria was categorized into 3 types according to urinary albumin-to- creatinine ratio: normal (<30 mg/g), microalbuminuria (MAU, 30-300 mg/g), and macroalbuminuria (≥300 mg/g). Measurement data were expressed as xˉ±s, and t-tests were used for comparisons between indicators. Qualitative data were expressed as rate or constituent ratio, and the χ2 test or Kruskal-Wallis test was used to examine differences. Logistic regression was used for multivariate analyses. SAS 9.4 software was used for statistical analyses, and P<0.05 was considered statistically significant. Results:The prevalence of abnormal albuminuria was 19.1%; the prevalence was 17.2% for MAU and lower in males (13.8%) than females (20.1%, P<0.01). The risk of CVD was higher among subjects with MAU ( OR=1.23, 95% CI 1.12-1.35) and macroalbuminuria ( OR=1.86, 95% CI 1.50-2.32). When MAU was complicated by hypertension and diabetes mellitus, the CVD risk was 1.76 times higher. Conclusions:The prevalence of MAU is high among Chinese subjects aged 35 years and over. Those with MAU have higher CVD risk, especially those with hypertension and diabetes mellitus.
