Intravoxel Incoherent Motion MR Imaging in the Head and Neck: Correlation with Dynamic Contrast-Enhanced MR Imaging and Diffusion-Weighted Imaging.
10.3348/kjr.2016.17.5.641
- Author:
Xiao Quan XU
1
;
Young Jun CHOI
;
Yu Sub SUNG
;
Ra Gyoung YOON
;
Seung Won JANG
;
Ji Eun PARK
;
Young Jin HEO
;
Jung Hwan BAEK
;
Jeong Hyun LEE
Author Information
1. Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, Korea. jeonghlee@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Head;
Neck;
Intravoxel incoherent motion;
Dynamic contrast-enhanced MRI;
Diffusion-weighted imaging;
Correlation;
IVIM;
DCE-MRI;
DWI
- MeSH:
Carcinoma, Squamous Cell;
Diffusion;
Head*;
Humans;
Magnetic Resonance Imaging*;
Masseter Muscle;
Muscles;
Neck*;
Perfusion;
Retrospective Studies
- From:Korean Journal of Radiology
2016;17(5):641-649
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To investigate the correlation between perfusion- and diffusion-related parameters from intravoxel incoherent motion (IVIM) and those from dynamic contrast-enhanced MR imaging (DCE-MRI) and diffusion-weighted imaging in tumors and normal muscles of the head and neck. MATERIALS AND METHODS: We retrospectively enrolled 20 consecutive patients with head and neck tumors with MR imaging performed using a 3T MR scanner. Tissue diffusivity (D), pseudo-diffusion coefficient (D*), and perfusion fraction (f) were derived from bi-exponential fitting of IVIM data obtained with 14 different b-values in three orthogonal directions. We investigated the correlation between D, f, and D* and model-free parameters from the DCE-MRI (wash-in, Tmax, Emax, initial AUC60, whole AUC) and the apparent diffusion coefficient (ADC) value in the tumor and normal masseter muscle using a whole volume-of-interest approach. Pearson's correlation test was used for statistical analysis. RESULTS: No correlation was found between f or D* and any of the parameters from the DCE-MRI in all patients or in patients with squamous cell carcinoma (p > 0.05). The ADC was significantly correlated with D values in the tumors (p < 0.001, r = 0.980) and muscles (p = 0.013, r = 0.542), despite its significantly higher value than D. The difference between ADC and D showed significant correlation with f values in the tumors (p = 0.017, r = 0.528) and muscles (p = 0.003, r = 0.630), but no correlation with D* (p > 0.05, respectively). CONCLUSION: Intravoxel incoherent motion shows no significant correlation with model-free perfusion parameters derived from the DCE-MRI but is feasible for the analysis of diffusivity in both tumors and normal muscles of the head and neck.
