Effects of 21-hydroxylase deficiency on male fertility

VernacularTitle:21-羟化酶缺陷症对男性生育力的影响
Author: Jing ZHOU ¹ ; Yunying CAI ; Heng SU
Author Information

1. 昆明理工大学医学院，云南省第一人民医院内分泌代谢科，昆明　650500
Keywords: Congenital adrenal hyperplasia; 21-Hydroxylase deficiency; Testicular adrenal rest tumor; Male; Fertility
From: Chinese Journal of Endocrinology and Metabolism 2023;39(5):453-455
CountryChina
Language:Chinese
Abstract: Congenital adrenal hyperplasia(CAH) is a group of autosomal recessive disorders caused by deficiency of specific enzymes in the adrenocortical hormone synthesis pathway, resulting in impaired corticosteroid synthesis. 21-hydroxylase deficiency is the most common type of CAH, and the disorder can lead to impaired fertility in patients. Most current studies have focused on fertility problems in female CAH patients. The most common causes of impaired fertility in men with 21-OHD include testicular adrenal rest tumors(TART), low gonadotropin secretion, and inappropriate glucocorticoid therapy. This article reviews the causes of impaired fertility and its treatment in male patients with 21-OHD, with the aim of providing guidance for improving the fertility of male patients with 21-OHD.