Thyroid hormone sensitivity and obesity phenotype in euthyroid subjects
10.3760/cma.j.cn311282-20221012-00579
- VernacularTitle:甲状腺功能正常人群中甲状腺激素敏感性与肥胖表型的关系
- Author:
Zixiao WANG
1
;
Sijue YANG
;
Haixia GUAN
;
Wei WANG
Author Information
1. 中国医科大学附属第一医院健康管理科，沈阳 110001
- Keywords:
Thyroid hormone sensitivity;
Thyroid Feedback Quantile-based Index;
Obesity phenotypes
- From:
Chinese Journal of Endocrinology and Metabolism
2023;39(5):426-429
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between thyroid hormone sensitivity and obesity phenotype in people with normal thyroid function.Methods:In this retrospective study, 6155 euthyroid subjects who underwent a health check-up in the First Hospital of China Medical University between January 2017 and December 2018 were included. Participants were categorized into four obesity phenotypes according to body mass index and metabolic status. Thyroid Feedback Quantile-based Index(TFQI), Parametric TFQI, free triiodothyronine to free thyroxine ratio(FT 3/FT 4), and sum activity of peripheral deiodinases(SPINA-GD) were calculated to evaluate thyroid hormone sensitivity. Results:Compared with metabolically healthy non-obese(MHNO) phenotype, the subjects with metabolically healthy obese(MHO) or metabolically unhealthy obese(MUO) phenotype showed higher FT 3/FT 4ratio. Metabolically unhealthy non-obese(MUNO) and MUO subjects showed lower TFQI. After adjusting for confounders, FT 3/FT 4ratio was positively associated with MHO( OR 1.18, 95% CI 1.11-1.26) and MUO phenotype( OR 1.28, 95% CI 1.19-1.39). With 1 s increase of TFQI, the OR for MUNO phenotype was 0.77(95% CI 0.64-0.94). The results of Parametric TFQI and SPINA-GD were similar to TFQI and FT 3/FT 4ratio, respectively. Conclusion:In euthyroid individuals, thyroid hormone sensitivity was positively associated with increased risk for unhealthy obesity phenotypes.
