Associations of human intestinal Dorea and glucose intolerance in people with obesity
10.3760/cma.j.cn311282-20230307-00099
- VernacularTitle:人类肠道 Dorea菌与肥胖患者糖耐量受损的相关性研究
- Author:
Shaoqian ZHAO
1
;
Huibin LIN
;
Weiqiong GU
;
Jie HONG
;
Ruixin LIU
Author Information
1. 上海交通大学医学院附属瑞金医院内分泌代谢科，上海 200025
- Keywords:
Obesity;
Gut microbiota;
Dorea;
Dorea formicigenerans;
Glucose intolerance
- From:
Chinese Journal of Endocrinology and Metabolism
2023;39(5):407-414
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the role of Dorea in glucose intolerance of people with obesity. Methods:This study recruited 113 young individuals with obesity and varying degree of glucose tolerance [body mass index(BMI)≥30 kg/m 2] and 105 controls, comparing the metabolic phenotypes and Dorea abundance. Correlation analysis and ROC analysis were performed to assess the association between Dorea and clinical parameters and its predictive role in predicting glucose intolerance. Results:(1) Metabolic parameters were higher in obesity group than the control group. There was no difference in body weight, BMI and WHR among subgroups classified by glucose tolerance in people with obesity. (2) The abundance of Dorea, Dorea formicigenerans were higher in obese individuals, however showing a downward trend in accordance with glucose intolerance. The abundance was inversely associated with OGTT-2 h plasma glucose and HbA 1C, while positively associated with HOMA-β. Logistic regression demonstrated that Dorea formicigenerans was an independent protective factor after adjusting confounders such as age and gender in the prevention of glucose intolerance. (3) ROC analysis exhibited that the AUC values of Dorea formicigenerans was 0.73 in the total population. Conclusion:Dorea and Dorea formicigenerans exert protective effect on glucose metabolism in obese subjects. The abundance of Dorea and Dorea formicigenerans can be used as predictors of glucose intolerance risk in obese subjects, which facilitate the early screening and monitoring.
