A case of Liddle syndrome and review of literature
10.3760/cma.j.cn311282-20220411-00220
- VernacularTitle:一个Liddle综合征家系临床和基因突变分析并文献复习
- Author:
Deyue JIANG
1
;
Xiaona HU
;
Xianling WANG
;
Jianming BA
;
Zhaohui LYU
;
Jingtao DOU
;
Weijun GU
;
Yiming MU
Author Information
1. 中国人民解放军总医院第一医学中心内分泌科，北京 100853
- Keywords:
Liddle syndrome;
SCNN1G;
Early-onset hypertension;
Aldosterone
- From:
Chinese Journal of Endocrinology and Metabolism
2023;39(3):261-264
- CountryChina
- Language:Chinese
-
Abstract:
The clinical data, laboratory test, and gene mutations were collected from a family with Liddle syndrome. Literatures on Liddle syndrome published in domestic and abroad since 1994 were reviewed and the types of gene mutations were summarized. The proband was diagnosed with hypertension at the age of 24. Laboratory test showed that serum potassium was 3.65 mmol/L, plasma renin was <0.5 mU/L, and plasma aldosterone was 1.5 ng/dL. Proband′s father was diagnosed with hypertension at the age of 34 with the serum potassium 3.34 mmol/L, plasma renin 3.72 mU/L, and plasma aldosterone 6.04 ng/dL. A nonsense mutation(1724G>A, p.Trp575*) in exon 13 of SCNN1G gene was detected in the proband and his father. In 288 cases from 107 families reported in the review of domestic and foreign literature, the incidence of hypertension, hypokalemia, and low renin/low aldosterone were 95.1%, 55.2%, and 49.6%, respectively. This case suggests that the clinical phenotype of Liddle syndrome is heterogeneous. Patients with early-onset hypertension, regardless of whether they are accompanied by hypokalemia, should be screened for renin-angiotensin-aldosterone and genetic testing related to Liddle syndrome should be further detected in patients with low plasma renin/aldosterone.
