Apical membrane antigen-1 (AMA-1) gene sequences of re-emerging Plasmodium vivax in South Korea.
10.3347/kjp.2002.40.3.157
- Author:
Eun Taek HAN
;
Jae Hwan PARK
;
Eun Hee SHIN
;
Min Ho CHOI
;
Myoung Don OH
;
Jong Yil CHAI
- Publication Type:Brief Communication ; Case Reports
- Keywords:
plasmodium vivax;
apical membrane antigen 1;
genotype;
Polymorphism;
Korea
- MeSH:
Adult;
Aged;
Amino Acid Sequence;
Animals;
*Antigens, Protozoan;
Base Sequence;
Child;
Female;
Genotype;
Human;
Korea;
Malaria, Vivax/*genetics;
Male;
Membrane Proteins/chemistry/*genetics;
Middle Aged;
Molecular Sequence Data;
Polymorphism (Genetics);
Protozoan Proteins/chemistry/*genetics;
Support, Non-U.S. Gov't
- From:The Korean Journal of Parasitology
2002;40(3):157-162
- CountryRepublic of Korea
- Language:English
-
Abstract:
Plasmodium vivax malaria re-emerged in South Korea in 1993, and epidemics continue since then. We examined genetic variation in the region encompassing the apical membrane antigen-1 (PvAMA-1) of the parasites by DNA sequencing of the 22 re-emerging P. vivax isolates. The genotype of the PvAMA-1, which was based on sequence data previously reported for the polymorphic regions, showed that two haplotypes were present at one polymorphic site. Compared with reported data, the two types, SKOR type I and type II, were similar to Chinese CH-10A and CH-05A isolates, respectively. Thus, the present study showed that two genotypes of AMA-1 genes coexist in the re-emerging Korean P. vivax.
