Effect of gender on anesthetic potency of ciprofol for gastroscopy when combined with fentanyl
10.3760/cma.j.cn131073.20221117.00515
- VernacularTitle:性别因素对复合芬太尼时环泊酚用于胃镜检查术麻醉效力的影响
- Author:
Chenxu WANG
1
;
Yan ZHOU
;
Yize LI
;
Yuan YUAN
;
Keliang XIE
;
Yonghao YU
Author Information
1. 天津医科大学总医院麻醉科 天津市麻醉学研究所，天津 300052
- Keywords:
Gastroscopy;
Sex factors;
Fentanyl;
Ciprofol
- From:
Chinese Journal of Anesthesiology
2023;43(5):585-587
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of gender on anesthetic potency of ciprofol for gastroscopy when combined with fentanyl.Methods:American Society of Anesthesiologists Physical Status classification Ⅰ or Ⅱ patients, aged 18-50 yr, with body mass index of 18-25 kg/m 2, undergoing elective gastroscopy with intravenous anesthesia, were divided into 2 groups according to gender: male group (M group) and female group (F group). After fentanyl 1.5 μg/kg was intravenously injected, ciprofol was given by the Dixon′s up-and-down method, with the initial dose of 0.4 mg/kg followed by dose increment/decrement of 0.04 mg/kg. The ED 50 and 95% confidence interval of ciprofol for gastroscopy anesthesia were calculated by the probit regression analysis. Results:The ED 50 (95% confidence interval) of ciprofol for gastroscopy was 0.33 (0.32-0.34) mg/kg in F group and 0.27 (0.26-0.28) mg/kg in M patients when combined with fentanyl 1.5 μg/kg. There was no significant difference between the two groups ( P>0.05). Conclusions:There is no significant gender difference in the anesthetic potency of ciprofol for gastroscopy (ED 50: female 0.33 mg/kg, male 0.27 mg/kg) when combined with fentanyl (1.5 μg/kg).
