Analysis of changes in plasma endothelin-1 concentrations in patients with acute respiratory distress syndrome
10.3760/cma.j.cn131073.20221010.00411
- VernacularTitle:急性呼吸窘迫综合征患者血浆内皮素-1浓度变化的分析
- Author:
Shan FENG
1
;
Yunpeng WANG
;
Xiyue CHENG
;
Dandan LI
;
Ru CUI
;
Boya JING
;
Haibin LI
;
Xing Ming FANG
;
Zhiyong WANG
Author Information
1. 河北医科大学第三医院全科医学科，石家庄 050051
- Keywords:
Endothelin-1;
Plasma;
Acute respiratory distress syndrome
- From:
Chinese Journal of Anesthesiology
2023;43(4):441-444
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the changes in plasma endothelin-1 (ET-1) concentrations in the patients with acute respiratory distress syndrome (ARDS).Methods:Fourteen patients with ARDS induced by trauma, 8 males and 6 females, aged 19-80 yr, were studied. The severity of ARDS was graded according to the Berlin definition of ARDS after admission to intensive care unit (ICU). Venous blood samples were obtained on 1st, 3rd and 5th days after admission to ICU, the plasma ET-1 concentrations were measured by radioimmunoassay, the pulmonary vascular permeability index (PVPI) was determined by PiCCO technique, and multiple organ dysfunction (MOD) score and lung injury score (LIS) were assessed. Spearman correlation of plasma ET-1 concentrations with MOD score, LIS and PVPI was analyzed.Results:MOD score, LIS, PVPI and plasma ET-1 concentrations were significantly decreased in mild ARDS patients ( n=5) as compared with moderate ARDS patients ( n=9, P<0.05). The plasma ET-1 concentration was positively correlated with MOD score, LIS and PVPI ( r=0.69, 0.76, 0.62, P<0.001). Conclusions:Plasma ET-1 concentrations can reflect the pulmonary vascular permeability and even the severity of the disease in the early stage of ARDS, so it is necessary to carry out dynamic monitoring in the patients.
