Risk factors for early acute lung injury after pediatric living-related liver transplantation and the predictive value
10.3760/cma.j.cn131073.20221018.00304
- VernacularTitle:小儿亲体肝移植术后早期急性肺损伤的危险因素及其预测价值
- Author:
Yingli CAO
1
;
Mingwei SHENG
;
Chen ZHANG
;
Jiahao ZHI
;
Yimei CAO
;
Hongyin DU
;
Wenli YU
Author Information
1. 南开大学医学院，天津 300071
- Keywords:
Child;
Liver transplantation;
Acute lung injury;
Risk factors
- From:
Chinese Journal of Anesthesiology
2023;43(3):274-277
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To identify the risk factors for early acute lung injury (ALI) after living-related liver transplantation in pediatric patients and evaluate the value of the risk factors in prediction of ALI.Methods:Perioperative data of patients were obtained through the electronic medical records system. Patients were divided into non-ALI group and ALI group according to whether ALI occurred within the first week after surgery. The risk factors of which P values were less than 0.05 would enter the multiple logistic regression analysis to stratify ALI-related risk factors. Area under the ROC curve was used to analyze the value of the risk factors in prediction of postoperative ALI. Results:A total of 67 patients were enrolled, including 45 cases in non-ALI group and 22 cases in ALI group. Increased intraoperative blood transfusion volume and up-regulated expression of miR-122 and miR-21 were independent risk factors for the occurrence of postoperative ALI ( P<0.05), and the area under the ROC curve (95% confidence interval) of serum miR-122 and miR-21 expression was 0.946 (0.875 to 1.00), with sensitivity and specificity of 95% and 90%, respectively. Conclusions:Increased intraoperative blood transfusion volume and up-regulated expression of serum miR-122 and miR-21 are independent risk factors for early postoperative ALI, and serum miR-122 and miR-21 levels have a high value in prediction of the development of postoperative ALI in pediatric patients undergoing living-related liver transplantation.
