Effects of remimazolam on gastrointestinal motor function in patients undergoing gastrointestinal endoscopy
10.3760/cma.j.cn131073.20221011.00117
- VernacularTitle:瑞马唑仑对胃肠镜检查术患者胃肠运动功能的影响
- Author:
Tianyi YANG
1
;
Xia GONG
;
Yanyan SUI
;
Lina ZHANG
;
Bing LIU
;
Mingshan WANG
;
Lixin SUN
;
Fei SHI
;
Yang YUAN
;
Gaofeng ZHANG
Author Information
1. 青岛市市立医院麻醉科，青岛 266071
- Keywords:
Benzodiazepines;
Gastroscopy;
Gastrointestinal motility
- From:
Chinese Journal of Anesthesiology
2023;43(1):80-83
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effects of remimazolam on gastrointestinal motor function in the patients undergoing gastrointestinal endoscopy.Methods:A total of 262 American Society of Anesthesiologists Physical Status classification Ⅰ or Ⅱ patients, aged 18-64 yr, with body mass index of 18-28 kg/m 2, scheduled for elective gastrointestinal endoscopy from May 2022 to August 2022, were divided into 2 groups ( n=131 each) using a random number table method: remimazolam group (group R) and propofol group (group P). The patients in group R received intravenous remimazolam 0.20-0.25 mg/kg, and patients in group P received intravenous propofol 1.5-2.0 mg/kg. The gastrointestinal endoscopy was performed when the patients′ Modified Observer′s Assessment of Alertness/Sedation scores ≤3. During fasting before gastrointestinal preparation, before gastrointestinal endoscopy and while leaving the post-anesthesia care unit (PACU), the concentrations of serum motilin and gastrin were measured by enzyme-linked immunosorbent assay, the intestinal peristalsis rating assessed by the endoscopist during the examination was recorded, the occurrence of hypotension and hypoxemia during the examination and occurrence of abdominal distension, abdominal pain, and nausea and vomiting during stay in PACU were recorded. Results:Compared with group P, the intestinal peristalsis rating was significantly increased, the serum motilin and gastrin concentrations were increased while leaving PACU, the incidence of hypotension and hypoxemia was decreased during the examination, and the incidence of abdominal distention was decreased during stay in PACU in group R ( P<0.05). Conclusions:Remimazolam has a milder inhibitory effect on secretion of gastrointestinal hormones than propofol in the patients undergoing gastrointestinal endoscopy and is helpful for the recovery of gastrointestinal motility.
