Effect of gender factor on efficacy of remimazolam combined with alfentanil in patients undergoing gastrointestinal endoscopy
10.3760/cma.j.cn131073.20221012.00116
- VernacularTitle:性别因素对瑞马唑仑复合阿芬太尼用于胃肠镜检查术患者效果的影响
- Author:
Dan CHENG
1
;
Zhihu YANG
;
Yanna LI
;
Yan LI
;
Mingcui QU
;
Wei ZHANG
;
Jianjun YANG
;
Na XING
Author Information
1. 郑州大学第一附属医院麻醉与围术期医学部，郑州 450052
- Keywords:
Sex factors;
Benzodiazepines;
Alfentanil;
Endoscopy, gastrointestinal
- From:
Chinese Journal of Anesthesiology
2023;43(1):76-79
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of gender factor on efficacy of remimazolam combined with alfentanil in the patients undergoing gastrointestinal endoscopy.Methods:Two hundred patients, aged 18-64 yr, with body mass index of 18-30 kg/m 2, of American Society of Anesthesiologists Physical Status classificationⅠor Ⅱ, scheduled for elective gastrointestinal endoscopy, were divided into 2 groups ( n=100 each) according to gender: male group (group M) and female group (group F). Remimazolam 0.2-0.3 mg/kg and alfentanil 5-7 μg/kg were intravenously injected, remimazolam 0.5-0.7 mg·kg -1·h -1 was continuously infused during operation to maintain the modified observer′s assessment of alert/sedation score<3 points, and alfentanil 2 μg/kg was administered when necessary. The consumption of remimazolam and alfentanil, examination time, recovery time and time of post-anesthesia care unit stay were recorded. The satisfaction scores of examination physicians and patients were recorded. The occurrence of adverse reactions such as injection pain, intraoperative body movement, respiratory depression, hypotension, bradycardia and hiccups and postoperative dizziness, nausea, vomiting, fatigue, abdominal pain and abdominal distension were recorded. Results:There was no significant difference in the consumption of remimazolam and alfentanil, examination time, recovery time, satisfaction scores of examination physicians and patients between the two groups ( P>0.05). There was no significant difference in the incidence of respiratory depression, hypotension, bradycardia, injection pain, body movement, hiccups, abdominal pain, abdominal distension, and fatigue between the two groups ( P>0.05). Compared with group M, the time of post-anesthesia care unit stay was significantly prolonged, and the incidence of postoperative dizziness, nausea and vomiting was increased in group F ( P<0.05). Conclusions:Remimazolam combined with alfentanil provides better efficacy in male patients than in female patients undergoing gastrointestinal endoscopy.
