Effect of esketamine on postoperative delirium in elderly patients undergoing general anesthesia
10.3760/cma.j.cn131073.20221012.01207
- VernacularTitle:艾司氯胺酮对全身麻醉老年患者术后谵妄的影响
- Author:
Jingya LUO
1
;
Jinyu LI
;
Hongfa WANG
;
Sheliang SHEN
;
Liang HAN
;
Xiaomin WU
;
Foquan LUO
Author Information
1. 蚌埠医学院研究生院，蚌埠 233030
- Keywords:
Ketamine;
Anethesia, general;
Aged;
Delirium
- From:
Chinese Journal of Anesthesiology
2022;42(12):1448-1451
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of esketamine on postoperative delirium (POD) in elderly patients undergoing general anesthesia.Methods:Two hundred and twenty-four elderly patients, aged ≥ 65 yr, with American Society of Anesthesiologists Physical Status classification Ⅰ-Ⅲ, undergoing elective surgery under general anesthesia, were divided into 2 groups ( n=112 each) using a random number table method: esketamine group (S group) and control group (C group). Esketamine 0.5 mg/kg was intravenously injected before anesthesia induction in S group, while the equal volume of normal saline was given instead in C group.The Fuzzy Consciousness Assessment Scale (3D-CAM) was used to assess the occurrence of POD within 7 days after surgery.The consumption of propofol, remifentanil and sufentanil and use of vasoactive drugs were recorded during operation.The rescue analgesia within 48 h after operation and occurrence of postoperative complications were recorded. Results:Compared with C group, the incidence of POD was significantly decreased, the intraoperative consumption of remifentanil was reduced, and the utilization rate of vasoactive drugs, rate of rescue analgesia and incidence of postoperative vertigo, nausea and vomiting within 48 h after surgery were decreased in S group ( P<0.05). Conclusions:Esketamine can reduce the development of POD in elderly patients.
