Research progress of targeted CD47 in the treatment of bladder cancer

VernacularTitle:靶向CD47在膀胱癌治疗中的研究进展
Author: Huayang QIN ¹ ; Mengfei WANG ; Yuxiong WANG ; Yuantao WANG
Author Information

1. 吉林大学白求恩第一医院泌尿外二科，长春　130021
Keywords: Urinary bladder neoplasms; Carcinoma; Integrin-associating protein; Targeted therapy
From: Chinese Journal of Urology 2023;44(5):398-400
CountryChina
Language:Chinese
Abstract: CD47 is a transmembrane glycoprotein widely expressed on cells and an important signal molecule for immune escape of tumor cells. CD47, which is highly expressed in bladder cancer cells, can interact with signal regulatory proteins on the surface of macrophages- α (SIRPα). It combines and transmits immunosuppressive signals to protect tumor cells from phagocytosis, thereby mediating their immune escape. CD47-SIRPα signal pathways have become the focus of tumor cell immune checkpoint research at this stage. This article reviewed the research progress in the mechanism and clinical value of CD47 in bladder cancer.