The Changing Pattern of Serum Prostate Specific Antigen in Patients with Benign Prostatic Hyperplasia after Combined Treatment with Finasteride and alpha-blockers: the 3 Year Follow-up Data.
10.4111/kju.2006.47.4.372
- Author:
Byung Hyun SOH
1
;
Jae Seok LEE
;
Byung Ha CHUNG
Author Information
1. Department of Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Prostatic hyperplasia;
Adrenergic antagonist;
Reductase;
Prostate specific antigen
- MeSH:
Adrenergic Antagonists;
Diagnosis;
Finasteride*;
Follow-Up Studies*;
Humans;
Lower Urinary Tract Symptoms;
Male;
Oxidoreductases;
Prostate*;
Prostate-Specific Antigen*;
Prostatic Hyperplasia*;
Retrospective Studies
- From:Korean Journal of Urology
2006;47(4):372-376
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Some recent studies have demonstrated that finasteride, a well- known 5alpha-reductase inhibitor, can decrease prostate specific antigen (PSA) by approximately 50% during the first 1 year of treatment. We investigated how long-term treatment with finasteride and alpha-blockers impacts on the serum PSA level of men whose final diagnosis was benign prostatic hyperplasia (BPH). MATERIALS AND METHODS: In a retrospective trial, we evaluated a total of 293 men with lower urinary tract symptoms (LUTS) that were suggestive of BPH. These men were divided into two treatment groups: group A was treated with alpha-blockers and group C was treated with a combination of finasteride and alpha-blocker. Comparisons of the two groups were performed by using independent t-tests. The changes in the PSA concentrations from baseline to the time of the final measurements were determined by repeated measures of ANOVA. RESULTS: There was no significant difference in the baseline PSA between the two groups. A statistically significant reduction in the PSA levels was observed at 2 years in C group (p<0.05), whereas any significant increase were not observed in group A (p>0.05). In group A, the repeatedly measured PSA levels were 2.67, 2.40, 2.41 and 2.42, respectively. In C group, these were 3.22, 2.09, 1.81 and 1.71 respectively. CONCLUSIONS: Our data showed that there was no clinically significant effect of long term treatment with alpha-blocker on the PSA levels. However, finasteride had significant effect on the serum PSA level during first two years of treatment.
